CROWN BIOSCIENCE|Biospecimen Services

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IHC · Spatial Transcriptomics · Single Cell Sequencing · Drug Profiling

Translational and Clinical Biomarker Services

From discovery through clinical development, we provide advanced biomarker technologies and human biospecimen-based services to support every stage of your research. Cutting-edge platforms combined with high-quality samples deliver insights that help you understand disease biology, identify targets, and evaluate therapeutic response.

Discuss Your Project

Our Approach

Seamless Workflows from Sample to Insight

Our unified approach minimizes complexity, reduces handoffs, and ensures a consistent chain of
custody — from patient sample to actionable results — helping you accelerate your research programs.

Assay Design & Sample Selection

Collaborative study design with scientific expertise. Access to high-quality human biospecimens matched to your protocol requirements.

Assay Design & Sample Selection

Collaborative study design with scientific expertise. Access to high-quality human biospecimens matched to your protocol requirements.

Assay Design & Sample Selection

Collaborative study design with scientific expertise. Access to high-quality human biospecimens matched to your protocol requirements.

Assay Design & Sample Selection

Collaborative study design with scientific expertise. Access to high-quality human biospecimens matched to your protocol requirements.

Platform Execution

Automated, validated workflows across IHC, Genomics and Proteomics functional assay platforms — with full QC at every step.

Data & Interpretation

Comprehensive data analysis, pathological evaluation, and scientific reporting. Integrated clinical data enables translational insights.

RUO Services
GCP Operations
CAP Accredited
Filed for CLIA

IHC & Pathology Services

Chromogenic and multiplex fluorescent immunohistochemistry with integrated digital pathology and image analysis for spatial protein expression characterization.

Genomics & Transcriptomics

From nucleic acid isolation through single-cell resolution and spatial context — the full spectrum of genomic analysis for translational research.

Proteomics & Cell Biology

Protein-level analysis and functional cell-based assays — from immunoassays to ex vivo drug profiling on patient-derived material.

Selected Highlights of Our Lab Services

Pathology Services

Immunohistochemistry (IHC)

Robust biomarker detection with high reproducibility and clinical-grade standards. Our immunohistochemistry services support your research from early discovery through clinical trials with automated, highly reproducible workflows and expert pathological evaluation.

  • Chromogenic and fluorescence multiplex IHC
  • Development and validation of custom assays
  • Established assays for 100+ targets
  • Automated staining platforms and standardized workflows
  • High-resolution whole slide imaging and digital image analysis
  • Histopathological evaluation by in-house board-certified pathologists

Gain reliable, spatially resolved insights into protein expression, co-localization, and tumor microenvironment composition to support biomarker discovery and translational research.

Chromogenic IHC

Chromogenic IHC

DAB, Fast Red, and dual chromogen detection. 500+ validated antibodies.

Multiplex Immunofluorescence

Multiplex Immunofluorescence

Up to 8 markers per section. Spatial tumor microenvironment profiling.

Fresh Frozen

Visium HD (10x Genomics)

Probe-based or polyA-based whole transcriptome analysis of FF and FFPE samples

Spatial Biology

Spatial Transcriptomics

Unlock gene expression of the whole transcriptome in its tissue context. Spatial transcriptomics enables the analysis of gene expression directly within intact tissue architecture, overcoming limitations of bulk RNA approaches.

Our end-to-end workflow:

  • Tissue preparation and sectioning (FF and FFPE samples)
  • High-resolution mapping of gene expression within tissue
  • Sequencing, visualization, and downstream data interpretation

Understand cellular heterogeneity and spatial organization to identify novel biomarkers and mechanisms of disease.

Genomics

Single Cell Gene Expression Analysis

Resolve cellular heterogeneity at single-cell resolution. Our single cell sequencing services provide deep insights into complex biological systems by profiling gene expression at the individual cell level.

  • Sequencing-based total mRNA analysis of dissociated cells
  • Single cell processing – Sample preparation and dissociation
  • Availability of various assays – probe-based or polyA-based
  • Library preparation, sequencing, and comprehensive data analysis

Reveal cellular heterogeneity, rare cell populations, immune dynamics, and functional states critical for precision medicine and drug development.

10X Genomics Chromium X platform

10X Genomics Chromium X platform

  • 10K+

    Cells per run

  • 3′ & 5′

    Flex Gene expression

Sample-to-Readout Workflow

Available readouts by input type

Precision-Cut Tumor Tissue Slices

Fresh tumor tissue → ex vivo culture → compound treatment

Tissue-Based

  • IHC & biomarker co-expression
  • Immune cell infiltration (TILs)
  • Gene expression profiling
  • Mutation status (NGS/PCR)

Functional

  • Cytotoxicity assays (viability)
  • Cytokine release profiling
  • Apoptosis / proliferation markers
  • Drug dose-response curves

Integrated Scientific Report

Multi-modal analysis · Pre/post-treatment comparison · Translational insights

Functional Assays

Drug Profiling Services

Predict therapeutic response in a physiologically relevant tumor model. Our drug profiling platform leverages precision-cut cancer tissue slices to evaluate drug effects in the native tumor microenvironment.

Available readouts:

  • Collection and preparation of human tumor tissue
  • Ex vivo culture and treatment with test compounds
  • Multi-modal analysis of drug response
  • Comprehensive scientific reporting with integrated data

Service components:

IHC & biomarker co-expression
Gene expression & mutation profiling
Immune cell infiltration & cytokine release
Spatial Transcriptomics

Generate highly predictive, translational data to support preclinical decision-making and therapy optimization.

Find the Right Samples for Your Study

Search our inventory or request a custom collection tailored to your specific inclusion/exclusion criteria. Our team of scientists is ready to help you select the ideal cohorts for your next project.

Biospecimen Request

Let’s Design Your Study Together

From assay design to data interpretation, our scientific team partners with you
across every stage. Tell us about your project and we’ll propose the right approach.

Contact Our Team

US: +1 (301) 228 9739

Germany: +49 40 69 63 572 0

busdev@biospecimenservices.com

Imprint

CROWN BIOSCIENCE|Global Biospecimen & Scientific Services

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