GBSS | Crown Bioscience

Delivering Premium Clinical Biospecimens Globally

Through partnerships with leading oncology centers across Europe, the United States, and Asia, our international clinical network enables consistent, high-quality biospecimen collection under fully standardized protocols.

Our own study nurses collect the specimen in the operation room or local staff members that are trained according to our SOPs with a focus on low ischemia time.

These highly standardized samples empower translational research and accelerates breakthroughs in cancer diagnostics and therapeutics.

Our logistics and lab team ensures the secure transport and processing of samples in state-of-the-art biobanking facilities designed for optimal sample handling and storage – with full tracking and traceability throughout the entire lifecycle.

alt-content-Delivering Premium Clinical Biospecimens Globally

Quality & Compliance

Built for Regulated Research

Globally Sourced Biobank

IRB-approved collections from all clinical sites. Diverse cohorts across 25+ tumor types.

Superior Sample Integrity

Ultra-short ischemic time protocols protect RNA, DNA, and protein signatures.

Deep Clinical Annotation

300+ data points per patient including treatment history, response, and mutation status.

End-to-End Compliance

HIPAA and GDPR proficiency. Full chain-of-custody documentation.

Our Biobank

Surgical Human Biobank

Curated for Oncology. Characterized for Translation.

FFPE, fresh-frozen, mutation-characterized, and viable fresh tissue across 25+ tumor types, with matched biofluids available for integrated analyses.

Biospecimen Biobank

Our globally sourced, IRB-approved biobank is purpose-built for translational and precision oncology research. High-quality tumor tissue, matched adjacent normal, plasma, serum, and PBMCs — all collected under standardized protocols with ultra-short ischemia times.

Each specimen is paired with extensive clinical data to support multi-omics applications, translational research, and diagnostic assay development.

Our collection covers a broad spectrum of cancer indications, including lung, colorectal, breast, prostate, liver, among many others.

Quality, Compliance, and Clinical Relevance

Rigorously controlled specimens collected under IRB-approved protocols and standardized workflows to ensure consistency and reproducibility.

Minimal ischemia time to preserve RNA, DNA, and protein integrity
Board-certified pathology review for every tissue specimen
Detailed clinical data including demographics, diagnosis, treatment history, and outcomes
HIPAA, GDPR, and GCP compliance throughout

Available Specimens

Specimen Types and Formats

Diverse cancer indications and healthy donors, preserved with validated workflows.
Each sample paired with extensive clinical metadata and the corresponded matched tissue or fluid.

Tissue Samples

Fresh-frozen or FFPE tumor tissue
Matched adjacent normal tissue
Tumor Tissue Microarray (TMA)
Available across multiple cancer types (e.g., colorectal, NSCLC, breast)

Blood-Derived Samples

Plasma, serum, buffy coat, PBMCs
Longitudinal collections available for time-course studies
Collected in EDTA or Streck ™, suitable for ctDNA, proteomics, cytokine profiling, and more

Custom Collections

Prospectively collected fresh tumor and adjacent normal tissue samples based on protocol specifications
Disease-state specific or treatment-naïve samples upon request
Tailored cohort design with IRB oversight

Longitudinal Plasma Collections

Track Disease Evolution Over Time

Our longitudinal cell-free plasma collections enable continuous monitoring of cancer progression across the treatment journey.

From Patient to Insight

Longitudinal Collection

Serial blood draws before during treatment.

Isolation of Circulating Tumor DNA

Streck Cell-free DNA BCT^® and ISO-aligned protocols.

Rich Clinical Data

Multiple therapies. Outcome data (30+ parameters).

High-Quality Biobank

Large patient cohort and indications. More than 700,000 samples.

Genomic & Biomarker Insights

Fully consented samples for advanced genomic and biomarker analysis

By capturing serial blood samples from the same patient, researchers can analyze circulating tumor DNA (ctDNA) to assess treatment response, detect resistance, and support biomarker development.

Disease Indications and Molecularly Stratified Cohorts

Well-characterized cohorts from treatment-naive, refractory, and relapsed populations — designed for targeted therapy development, immuno-oncology research, and translational studies.

Our oncology specimen portfolio includes NSCLC, breast, prostate, colorectal, liver, pancreatic, ovarian, melanoma, and other solid tumors. Sub-cohorts include driver mutations (EGFR, KRAS, BRAF, PIK3CA), treatment history stratification, and histopathology confirmation with tumor content verification.

Find the Right Samples for Your Study

Search our inventory or request a custom collection tailored to your specific inclusion/exclusion criteria. Our team of scientists is ready to help you select the ideal cohorts for your next project.

Biospecimen Request

Specimen Grades

Multi-Omics vs. Standard Grade

Two tiers of human biospecimens to match your research needs. Both backed by our global
sourcing, minimized ischemia times, and clinical annotation.

Multi-Omics Grade

Multi-Omics Grade Biospecimens

Designed for genomic, transcriptomic, proteomic, and spatial biology applications. Ultra-short ischemic time, 300+ clinical data points, and validated molecular integrity for high-precision, data-rich analysis.

Standard Grade

Standard Grade Biospecimens

Optimized for high-throughput screening, diagnostic validation, and cost-conscious projects. Stringent quality standards with practical scale and competitive pricing.

Laboratory Services

Pathology Services and Multi-Omics Solutions

Available as standalone services or integrated with biospecimens. All pathology reviewed by
in-house board-certified pathologists.

Service	Description and Key Features	Primary Applications
Pathology Services
Immunohistochemistry (IHC)	Protein detection and localization using 500+ pre-validated antibodies. Chromogenic and multiplex fluorescent platforms (Ventana, Leica, Dako).	Target expression, biomarker localization, patient stratification
Multiplex Immunofluorescence	Simultaneous detection of up to 8 biomarkers on a single tissue section for spatial insights into the tumor microenvironment.	Immuno-oncology, spatial biology, complex protein interaction
Multi-Omics Solutions
Genomics & Transcriptomics	DNA/RNA isolation, NGS, qPCR, FISH, laser capture microdissection, 10x Chromium single-cell, and Visium spatial transcriptomics.	Mutation analysis, gene expression, spatial profiling
Proteomics & Cell Biology	ELISA, MSD, Simple Western, flow cytometry, TIL isolation, drug profiling on patient-derived material.	Protein expression, target validation, functional assays
Integrated Clinical Data	Specimens linked with extensive clinical data for correlating molecular findings with patient outcomes and treatment response.	Translational research, precision medicine, therapeutic response prediction

Frequently Asked Questions

Common Questions

When to use fresh-frozen or FFPE tissue?

Fresh-frozen tissue is considered the gold standard for applications requiring high-quality nucleic acids (DNA/RNA) and proteins, making it ideal for genomics and proteomics. FFPE tissue is a stable, long-term storage format excellent for histology, immunohistochemistry (IHC), and retrospective studies. We offer both to match your specific research needs.

Can you provide custom biospecimen collections?

Yes, we offer custom prospective collections to meet unique research criteria, including specific disease indications, treatment histories, and patient demographics. Our global clinical network allows us to source the precise samples you need.

How do you handle logistics and shipping?

We use a fully traceable, barcode-based inventory system and validated cold-chain logistics to ensure sample integrity from our biobank to your lab. We manage all shipping and regulatory documentation through Biocair, our trusted logistics partner.

What clinical data accompanies each specimen?

Each specimen includes 300+ data points: patient demographics, tumor classification, therapy and treatment history, tumor response data (CR/PR/SD/PD), mutation status for key biomarkers if available (EGFR, KRAS, BRAF, HER2, PD-L1, ALK, MSI), and radiology data upon request.

Can you support multi-omics research?

Yes. Our specimens are collected with minimal ischemic time to preserve the integrity of DNA, RNA, and protein — the foundation for integrated multi-omics analysis. We also offer in-house genomics, transcriptomics, proteomics, and spatial biology services to complete the workflow.

Powering Your Next Breakthrough

Ready to accelerate your oncology research with high-quality human
biospecimens? Our scientific team is ready to partner with you.

Contact Our Team

US: +1 (301) 228 9739

Germany: +49 40 69 63 572 0

busdev@biospecimenservices.com

Imprint

Human Biospecimen Solutions for Precision Oncology Research